Sermorelin

Sermorelin is a prescription medicine that may help adults with increasing muscle mass, energy and endurance and prevent sarcopenia (loss of muscle mass), especially while on a reduced calorie diet and GLP-1 therapy. It can also have anti-aging benefits and may also help to improve libido and sexual performance.   

Sermorelin is a modified version of a naturally occurring substance that causes release of growth hormone from the pituitary gland. Growth hormones are naturally produced by the pituitary gland and are necessary for growth. Sermorelin injections can help to restore the levels of HGH, allowing you to regain your youthful energy and vitality.

Sermorelin is not a steroid and should not be confused with treatments such as testosterone, progesterone, estrogen or human growth hormone replacement.

With Sermorelin, nothing is being replaced in your body. Sermorelin peptide will help your pituitary gland produce large amounts of its own growth hormone.

It takes time to see results with Sermorelin, with an average of 3-6 months of treatment to see clinical improvements.

Who should not use compounded sermorelin? 

 Do not use compounded Sermorelin if: 

• You have a known allergic reaction to sermorelin-containing products or products that include human Growth Hormone Releasing Peptides (hGHRPs) 

• Breastfeeding 

• Pregnant   

• Current benign or cancerous tumor(s) 

You may not be advised to take Sermorelin if you take:

• Thyroid Medication 

• Steroids 

• Type 2 Diabetes—can affect glucose levels 

• Chronic use of immunosuppressive therapy 

• hGH medication  

Side Effects:

Rare but serious: Anaphylaxis/Allergic Reaction (trouble breathing, swallowing)

Most Common:

• Itching  

• Flushing 

• Dizziness 

• Flushing 

• Headache 

• Sleepiness 

• Trouble sitting still 

Sermorelin comes in a vial containing 15mg total. Unlike most of our other medications, Sermorelin has an extra step in preparation. It comes in a lyophilized powder that must be mixed:

• Step 1: Mix the Bacteriostatic water provided into the vial of Sermorelin using a large “mixing syringe” with attached needle. This is done by using the mixing syringe to draw the appropriate amount of bacteriostatic water and dispensing it into the vial of Sermorelin. Usually the mixing syringe is between 3ML and 10ML in size (not to be confused with the much smaller syringes used to inject). 
For 15mg vial of Sermorelin: using the mixing syringe, dilute (mix) 7.5ml of bacteriostatic water.

• Step 2: Next, swirl the vial with a gentle rotary motion until contents are dissolved- DO NOT SHAKE

• Step 3: Now you are ready to administer your Sermorelin. Please note that 10 units on the syringe = 200mcg of Sermorelin when measured on the syringe used to inject, usually an “insulin” syringe. So if your prescribed dose is 800mcg, this means you draw to the 40 unit mark on the syringe.

Storage: You may use this mixture for up to 90 days, but remember to keep it refrigerated after mixing. If you accidentally leave your sermorelin out of the fridge, it is safe at room temperature for 72 hours after being mixed.

The injection should be given via subcutaneous injection

As stated above, this medication comes in a lyophilized powder which you will need to mix with bacteriostatic water (water and all supplies are included). See an example video on how to mix it here: How to Mix Peptides

★ Dosing:

Starting 0.2mL/20 units 5 nights per week (400mcg/dose)

Mid 0.3mL/30 units 5 nights per week (600mcg/dose)

High 0.4mL/40 units 5 nights per week (800mcg/dose)

We typically recommend starting at the Mid dosing level for most patients. You can titrate up or down based on your individual response.